Evrys Bio
Evrys Bio’s pipeline is designed to rapidly generate proof-of-concept data
Our platform technology modulates SIRT2 to shift metabolism and coordinate metabolic reprogramming during infection.
SIRT2 is part of a family of proteins called sirtuins, NAD+-dependent deacylases that play key roles in regulating various cellular processes.
In low nutrient cellular environments, such as during a viral infection, NAD+ levels increase which upregulates SIRT2 activity
SIRT2 modulation shifts metabolic reprogramming in the host cell to create a cellular environment unfavorable to any virus
Our small molecule platform enables fine-tuning of SIRT2 modulation, allowing us to produce drugs with unique binding properties that are optimized for use against different viral profiles, different indications, and different therapeutic areas.
Publications: